Well, the MZR engine can be a bit "tempermental" when being pushed beyond what it's comfortable with.
For starters, it's very important to maintain a DI fuel pressure of at least 1600PSI at wide open throttle (WOT)...anything less can mean that your cam-driven fuel pump is unable to meet the fueling demands that are necessary to keep the engine from running too lean. When the engine runs too lean you'll run into the problem of detonation which will definitley shorten the life of the engine (you'll probably end up bending a rod and venting your block)
Too high of a knock retard value will also be an indicator of possible detonation and so it should also be monitored. Getting a monitoring device will allow you to keep an eye on these parameters (as well as others) and should be seen as an investment in your car's health/longevity.
Now, if you're running completely stock then the chances of running into fuel pump limitations or high counts of knock are much less likely, but still not impossible. I prefer to err on the side of caution.
As far as driving the car as if it were normally aspirated, what I meant by that was going WOT below 2500RPM (which will cause undue load on the engine) and going WOT in 6th gear (which is meant more for cruising RPM). I've known a lot of people that just mash the gas whenever the mood strikes them...a NA car is far more forgiving of that than the Speed would be.